Car use creates significant externalities for urban residents worldwide. City characteristics such as the configuration of the urban landscape and street network likely influence the use and attractiveness of automobiles, especially in rapidly urbanizing areas such as Latin America. The understanding of factors associated with motorization can inform planning measures to reduce car usage, and to promote healthier, safer, and more sustainable urban lifestyles. We harmonized official passenger vehicle data from 300 cities with >100,000 inhabitants in Brazil, Chile, Colombia, and Mexico, and...